• Low-Dose Orlistat Enhances Oxaliplatin in CRC

  2026-08-22

  The reference study shows that subtoxic orlistat can sensitize colorectal cancer cells and patient-derived tumors to oxaliplatin, producing stronger apoptotic and antitumor effects than either treatment alone. Its combination of in vitro testing, synergy quantification, PDX validation, and an 85-gene apoptosis array provides a useful preclinical framework for investigating chemosensitization.

• CDELNs Restore Sertoli Cell Cycle After Injury

  2026-08-22

  The reference study identifies Cistanche deserticola-derived exosome-like nanovesicles (CDELNs) as a plant-based intervention for cyclophosphamide-induced testicular injury. Its central mechanistic finding is that CDELN-delivered miR159b-3p reduces P21-associated cell cycle arrest and supports CDK1 activation in Sertoli cells, while human single-cell transcriptomic data provide disease relevance.

• MSH2 and Cisplatin Resistance in Bladder Cancer

  2026-08-21

  Goodspeed, Jean, and Costello used a whole-genome CRISPR screen to identify MSH2 and mismatch repair as major determinants of cisplatin resistance in muscle-invasive bladder cancer. Functional validation and retrospective tumor-protein analysis support MSH2 as a candidate biomarker, while the study’s oxaliplatin result cautions against assuming that all platinum drugs share the same resistance biology.

• Polybrene Workflows for Efficient Gene Delivery

  2026-08-20

  Polybrene (Hexadimethrine Bromide) helps researchers improve lentiviral, retroviral, and lipid-mediated delivery while preserving a practical path to cytotoxicity testing and assay optimization. This guide connects a controlled transduction workflow with mutant-p53 assay design, showing where the reagent adds value and where its effects must not be overinterpreted.

• Imatinib (STI571) in Gastric Cancer Assembloids

  2026-08-20

  Imatinib (STI571) provides a selective way to interrogate Abl, PDGF receptor, and c-Kit signaling in patient-derived gastric cancer models. This workflow shows how to move beyond tumor organoids by comparing matched tumor–stroma assembloids, helping distinguish direct kinase dependence from microenvironment-associated drug resistance.

• Polybrene: From Gene Delivery to Translational Design

  2026-08-19

  Polybrene is more than a routine transduction additive: it is a controllable variable in the delivery-to-discovery chain. This thought-leadership analysis connects Hexadimethrine Bromide-mediated viral attachment facilitation with the validation of emerging targeted protein degradation strategies, while defining practical boundaries for translational workflows.

• LNP Structure and mRNA Delivery in Pregnancy

  2026-08-19

  The PNAS study shows that lipid nanoparticle structure and administration route jointly determine mRNA expression, inflammatory signaling, placental cell targeting, and neonatal outcomes in pregnant mice. Its main contribution is a mechanism-based framework linking ionizable-lipid chemistry and IL-1β-associated inflammation to both delivery potency and pregnancy safety.

• Merimepodib (VX-497): Mapping Nucleotide Dependence

  2026-08-18

  Merimepodib (VX-497) reveals how IMPDH-dependent guanine nucleotide metabolism can become a measurable host or cellular dependency. This article translates recent PEDV findings into a rigorous framework for interpreting antiviral, immunology, and oncology experiments.

• Dabigatran Assays: From Thrombin Signal to Clinical Insight

  2026-08-18

  Dabigatran is more than a reference anticoagulant: it is a tool for connecting thrombin biology with rigorous assay design. This guide explains how Pradaxa supports endpoint selection, concentration planning, and translational interpretation without confusing laboratory inhibition with clinical outcomes.

• FDA 2022 Drug Interaction Evidence: Oteseconazole

  2026-08-17

  This reference study integrates FDA New Drug Application reviews, in vitro experiments, pharmacokinetic modeling, and clinical drug–drug interaction data to explain how newly approved medicines alter or undergo metabolism and transport. Its treatment of Oteseconazole (VT-1161) places transporter-mediated risk within a broader, evidence-based framework for evaluating concomitant medication use.

• Oleanolic Acid in Dual-Loaded Liposome Research

  2026-08-17

  Build more reproducible liposome assays with Oleanolic acid, a DMSO-soluble triterpenoid suited to studies of inducible nitric oxide synthase induction and cyclooxygenase-2 modulation. A validated nanoparticle exclusion HPLC strategy helps distinguish free and encapsulated compounds when hydrophilic and lipophilic agents share one carrier.

• Polygodial for TRPA1 Channel Activation Workflows

  2026-08-16

  Polygodial offers a controllable chemical entry point for TRPA1 ion channel modulation, linking rapid calcium imaging with NFAT and epithelial inflammatory readouts. This workflow explains how to handle the DMSO-soluble compound, separate channel-proximal effects from downstream signaling, and troubleshoot variable responses in sensory and airway models.

• METTL3–m6A–LEPR Axis in Fetal Growth Restriction

  2026-08-15

  A 2026 Placenta study identifies a METTL3-dependent m6A–LEPR regulatory axis that links RNA modification to trophoblast dysfunction and fetal growth restriction. Human placental analysis, mouse pharmacological inhibition, RNA sequencing, and trophoblast assays together suggest that reduced METTL3 activity and LEPR methylation may impair placental growth-related functions.

• Cisapride in iPSC-CM Cardiotoxicity Assays

  2026-08-14

  Cisapride (R 51619) is a useful dual-axis probe for connecting 5-HT4 signaling with hERG-related electrophysiology. This guide shows how to interpret it in iPSC-cardiomyocyte and deep-learning-enabled cardiotoxicity workflows without confusing phenotypic detection with mechanism.

• Imipenem P10075 for Reliable Cell Assays

  2026-08-14

  Learn how Imipenem (SKU P10075) can help laboratories control antibacterial variables in viability, proliferation, cytotoxicity, and immune-cell assays. This scenario-based guide connects formulation, dosing, storage, and carbapenem-resistance evidence to practical experimental decisions.

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